692054-06-1

Name	AZD0424
CAS	692054-06-1
Molecular Formula	C25H29ClN6O5
MDL Number	MFCD32201036
Molecular Weight	528.99
MOL File	692054-06-1.mol

Synonyms

AZD0424 AZD0424,AZD-0424 Ethanone, 1-[4-[2-[[4-[(6-chloro-1,3-dioxolo[4,5-b]pyridin-7-yl)amino]-5-(1-methylethoxy)-7-quinazolinyl]oxy]ethyl]-1-piperazinyl]-

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Hazard Information

Uses

AZD0424 is an orally active, and dual selective Src/Abl kinase inhibitor with potential antineoplastic activity[1]. AZD0424 induces apoptosis and cell cycle arrest in lymphoma cells[2].

References

[1] Woodcock VK, et al. A first-in-human phase I study to determine the maximum tolerated dose of the oral Src/ABL inhibitor AZD0424. Br J Cancer. 2018 Mar 20;118(6):770-776. DOI:10.1038/bjc.2017.484
[2] Nowak D, et al. Src kinase inhibitors induce apoptosis and mediate cell cycle arrest in lymphoma cells. Anticancer Drugs. 2007 Oct;18(9):981-95. DOI:10.1097/CAD.0b013e3281721ff6

Supplier

Fan De(Beijing) Biotechnology Co., Ltd.

Telephone 15911056312

Websitehttp://www.bio-fount.com/

Suzhou Meishi Biotechnology Co., Ltd.

Telephone 1173954148q

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1822805/0_EN.htm

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Biosynth Biological Technology (Suzhou) Co Ltd

Telephone 51288865780

Websitehttp://www.biosynth.com

Adooq Bioscience LLC

Telephone400-025-6535

Websitehttp://www.adooq.cn

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