68978-04-1

Mulberrofuran A can inhibit the formations of 12-hydroxy-, 8, 10-heptadecatrienoic acid (HHT) and thromboxane B2, but it can increase the formation of 12-hydroxy-5, 8, 10, 14-eicosatetraenoic acid (12-HETE).

Mulberrofuran A is a natural product, that can be isolated from the root bark of mulberry tree. Mulberrofuran A inhibits the formations of 12-hydroxy-,8,10-heptadecatrienoic acid (HHT) and thromboxane B2 (cyclooxygenase products), but it increases the formation of 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) (12-lipoxygenase product)[1].

ChEBI: Mulberrofuran A is a member of 1-benzofurans.

COX

[1] Kimura Y, et al. Effects of flavonoids and related compounds from mulberry tree on arachidonate metabolism in rat platelet homogenates. Chem Pharm Bull (Tokyo). 1986 Mar;34(3):1223-7. DOI:10.1248/cpb.34.1223