673443-80-6

DCE_254 is a novel EZH2 inhibitor that also displays significant anti-proliferation activity against lymphoma cell lines.

DCE_254 is an EZH2 inhibitor (IC50=11 μM) that also exhibits significant antiproliferative activity against lymphoma cell lines. DCE_254 inhibits the development of hypermethylation-related cancers by inhibiting the SAM-mediated methyl transfer process (IC50=10.3 μM)[1].

[1] Wu Y, et al. Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays[J]. Bioorganic & Medicinal Chemistry Letters, 2016, 26(15): 3813-3817. DOI:10.1016/j.bmcl.2016.05.018