ChemicalBook CAS DataBase List 67262-86-6

67262-86-6

Name	TN ANTIGEN
CAS	67262-86-6
Molecular Formula	C11H20N2O8
MDL Number	MFCD01863462
Molecular Weight	308.29
MOL File	67262-86-6.mol

Synonyms

TN EPITOPE TN ANTIGEN GALNAC-ALPHA1-O-SER Ser(α-D-GalNHAc)-OH GalNac-α-1-O-serine N-ACETYLGALACTOSAMINE, ALPHA1-O-SERINE N-Acetyl-α-D-galactosaMinyl- 1-O-serine N-ACETYL-ALPHA-D-GALACTOSAMINYL-1-O-SERINE SERINYL 2-ACETAMIDO-2-DEOXY-A-GALACTOPYRANOSIDE 2-Acetamido-2-deoxy-a-D-galactopyranosyl serine Serinyl 2-AcetaMido-2-deoxy-α-galactopyranoside O-[2-(AcetylaMino)-2-deoxy-α-D-galactopyranosyl]- O-[2-(Acetylamino)-2-deoxy-α-D-galactopyranosyl]-L-serine L-Serine, O-[2-(acetylamino)-2-deoxy-α-D-galactopyranosyl]- O-[2-(Acetylamino)-2-deoxy-alpha-D-galactopyranosyl]-L-serine Serinyl 2-acetamido-2-deoxy-a-galactopyranoside, N-acetyl-a-D-galactosaminyl-1-O-serine Serinyl 2-acetamido-2-deoxy-α-galactopyranoside, N-acetyl-α-D-galactosaminyl-1-O-serine

Chemical Properties

Melting point	198-201°C
Boiling point	701.2±60.0 °C(Predicted)
density	1.51±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Water
form	Solid
pka	2.05±0.10(Predicted)
color	Off-White to Yellow
Stability:	HYGROSCOPIC
InChI	1S/C11H20N2O8/c1-4(15)13-7-9(17)8(16)6(2-14)21-11(7)20-3-5(12)10(18)19/h5-9,11,14,16-17H,2-3,12H2,1H3,(H,13,15)(H,18,19)/t5-,6+,7+,8-,9+,11-/m0/s1
InChIKey	REDMNGDGDYFZRE-WKWISIMFSA-N
SMILES	CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@H](N)C(O)=O

Safety Data

WGK Germany	3
Storage Class	11 - Combustible Solids

Hazard Information

Chemical Properties

TN ANTIGEN is Yellow Solid

Uses

A cancer associated carbohydrate tumor antigen which may be effective as cancer specific targets for immunotherapy as well as in the development of diagnostic monoclonal antibodies. Has been used or considered for use in human vaccines.

Uses

TN ANTIGEN is a cancer associated carbohydrate tumor antigen which may be effective as cancer specific targets for immunotherapy as well as in the development of diagnostic monoclonal antibodies. Has been used or considered for use in human vaccines

Definition

ChEBI: O-(N-acetyl-alpha-D-galactosaminyl)-L-serine is a non-proteinogenic L-amino acid that is N-acetyl-alpha-D-galactosamine linked via an alpha glycosidic bond to the O at position 3 of L-serine. It has a role as a tumour antigen. It is a L-serine derivative and a non-proteinogenic L-alpha-amino acid.

General Description

Tn antigen?is a truncated O-glycan, that is commonly noticed in colorectal cancer (CRC). It is usually expressed at high levels in cancer cells. Tn antigen is small in size and simple in structure. It has a non-physiological glycan structure in humans, hence it may be identified as foreign by the immune system.

Biochem/physiol Actions

Tn antigen stimulates colorectal cancer metastasis through the activation of epithelial-mesenchymal transition, mediated by H-Ras. It acts as a precursor to several significant complex O-glycans. Subpopulations of blood cells in all lineages carrying the Tn antigen results in a hematological disorder called Tn syndrome.

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