ChemicalBook CAS DataBase List 67262-86-6

67262-86-6

Name	TN ANTIGEN
CAS	67262-86-6
Molecular Formula	C11H20N2O8
MDL Number	MFCD01863462
Molecular Weight	308.29
MOL File	67262-86-6.mol

Chemical Properties

Melting point	198-201°C
Boiling point	701.2±60.0 °C(Predicted)
density	1.51±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Water
form	Solid
pka	2.05±0.10(Predicted)
color	Off-White to Yellow
Stability:	HYGROSCOPIC

Safety Data

WGK Germany

Hazard Information

Chemical Properties

TN ANTIGEN is Yellow Solid

Uses

A cancer associated carbohydrate tumor antigen which may be effective as cancer specific targets for immunotherapy as well as in the development of diagnostic monoclonal antibodies. Has been used or considered for use in human vaccines.

Uses

TN ANTIGEN is a cancer associated carbohydrate tumor antigen which may be effective as cancer specific targets for immunotherapy as well as in the development of diagnostic monoclonal antibodies. Has been used or considered for use in human vaccines

Definition

ChEBI: O-(N-acetyl-alpha-D-galactosaminyl)-L-serine is a non-proteinogenic L-amino acid that is N-acetyl-alpha-D-galactosamine linked via an alpha glycosidic bond to the O at position 3 of L-serine. It has a role as a tumour antigen. It is a L-serine derivative and a non-proteinogenic L-alpha-amino acid.

General Description

Tn antigen?is a truncated O-glycan, that is commonly noticed in colorectal cancer (CRC). It is usually expressed at high levels in cancer cells. Tn antigen is small in size and simple in structure. It has a non-physiological glycan structure in humans, hence it may be identified as foreign by the immune system.

Biochem/physiol Actions

Tn antigen stimulates colorectal cancer metastasis through the activation of epithelial-mesenchymal transition, mediated by H-Ras. It acts as a precursor to several significant complex O-glycans. Subpopulations of blood cells in all lineages carrying the Tn antigen results in a hematological disorder called Tn syndrome.

Supplier

J & K SCIENTIFIC LTD.

Telephone010-82848833 400-666-7788

Websitehttp://www.jkchemical.com

3B Pharmachem (Wuhan) International Co.,Ltd.

Telephone821-50328103-801 18930552037

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13285/0.htm

Chemsky（shanghai）International Co.,Ltd.

Telephone021-50135380

Websitehttp://www.shchemsky.com

Guangzhou Isun Pharmaceutical Co., Ltd

Telephone020-39119399 18927568969

Websitehttp://www.isunpharm.com

Sigma-Aldrich

Telephone021-61415566 800-8193336

Websitehttps://www.sigmaaldrich.cn

Shanghai EFE Biological Technology Co., Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Beijing OKA biological technology co., LTD

Telephone010-010-010-62971590 18548936886

Websitehttp://www.bjoka-vip.com/

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Telephone+86-400-002-6226 +86-13028896684;

Websitehttps://www.rrkchem.com

Beijing xinyanhui pharmaceutical research and development co., LTD

Telephone 13969155946

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList710437/0.htm

Hangzhou Jinghao Biotechnology Co., LTD

Telephone17513242016 17513242016

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1421058/0.htm

Energy Chemical

Telephone021-58432009 400-005-6266

Websitehttp://www.energy-chemical.com

Shanghai Haohong Scientific Co., Ltd.

Telephone400-400-8210725

Websitehttps://www.leyan.com/

Shanghai Saikerui Biotechnology Co. , Ltd.

Telephone021-58000709 15900491054

Websitehttp://www.scrbio.com/

Shenzhen Excellent Biomedical Technology Co., Ltd.

Telephone 18318671572

Websitehttps://www.ex-biotech.com/

Shanghai Beiwanta Biotechnology Co., Ltd.

Telephone021-67187366 19901745723

Websitehttp://www.bwtlab.com/

Accela ChemBio Co.,Ltd.

Telephone021-50795510 4000665055

Websitehttps://www.shao-yuan.com

Young&Lively Pharminblock Co,.Ltd.

Telephone 18600731423

Website

SHANGHAI ZZBIO CO., LTD.

Telephone15102117276 19921389125

Websitehttps://www.zzsrm.cn/

1of4

Send Inquriy