66640-93-5

Name	DFMO
CAS	66640-93-5
Molecular Formula	C6H12F2N2O2
MDL Number	MFCD00221766
Molecular Weight	182.17
MOL File	66640-93-5.mol

Synonyms

DFMO L-DFMO L-RMI71782 EFLORNITINE L-Eflornithine H-DL-(F2ME)ORN-OH DIFLUOROMETHYLORNITHINE L-α-difluoromethylornithine H-ALPHA-DIFLUORO-ME-DL-ORN-OH ALPHA-DIFLUORO-ME-DL-ORNITHINE L-alpha-Difluoromethylornithine DL-ALPHA-DIFLUOROMETHYLORNITHINE L-Ornithine, 2-(difluoromethyl)- ALPHA-DIFLUOROMETHYL-DL-ORNITHINE H-DL-(ALPHA-DIFLUOROMETHYL)ORN-OH

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Chemical Properties

Boiling point	347.0±42.0 °C(Predicted)
density	1.293±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
pka	1.22±0.44(Predicted)

Hazard Information

Uses

L-Eflornithine (L-DFMO) is an enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 μM, and a Kinact of 0.15±0.03 min-1[1].

Biological Activity

L-Eflornithine (L-DFMO) is the enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with KD of 1.3±0.3 μM and Kinact of 0.15±0.03 min-1.

in vivo

The more potent L-Eflornithine is present at much lower concentrations in both plasma and cerebrospinal fluid (CSF) than those of the D-Eflornithine. The plasma concentrations of L-Eflornithine are on average 52% of the D -enantiomer concentrations. The typical oral clearances of L-Eflornithine and D-eflornithine are 17.4 and 8.23 liters/h, respectively.

target

KD: 1.3±0.3 μM (Ornithine decarboxylase, ODC)

storage

Store at -20°C

References

[1] Qu N, et al. Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine. Biochem J. 2003 Oct 15;375(Pt 2):465-70. DOI:10.1042/BJ20030382
[2] Jansson-L?fmark R, et al. Enantiospecific reassessment of the pharmacokinetics and pharmacodynamics of oral eflornithine against late-stage Trypanosoma brucei gambiense sleeping sickness. Antimicrob Agents Chemother. 2015 Feb;59(2):1299-307. DOI:10.1128/AAC.04101-14

Supplier

Sanover (Xiamen) Technology Co., Ltd

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Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1787465/0_EN.htm

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

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