Chemical Properties
Pale Yellow Solid
Uses
N-Cyanoacetylurethane is used in the synthesis of inhibitors targetting the PDZ domain of PICK1, which is a potential target for brain ischemia, pain and addiction illnesses. Also it is used in the sy
nthesis of cathespin K inhibitors.
Uses
N-Cyanoacetylurethane is used in the synthesis of inhibitors targetting the PDZ domain of PICK1, which is a potential target for brain ischemia, pain and addiction illnesses. Also it is used in the synthesis of cathespin K inhibitors.
Reactions
N-Cyanoacetylurethane has multiple reactivity and can participate in diazotization reactions and coordinate reactions with metal complexes.
Synthesis
2-Cyanoacetic acid was reacted with ethyl carbamate, DMF and phosphorus oxychloride, and finally extracted with ethyl acetate to obtain N-Cyanoacetylurethane.
References
[1] Patent: WO2014/190199, 2014, A1. Location in patent: Paragraph 00250
[2] Patent: WO2016/81522, 2016, A1. Location in patent: Paragraph 00284; 00285; 00290
[3] Organic and Biomolecular Chemistry, 2010, vol. 8, # 19, p. 4281 - 4288
[4] Patent: US2013/252958, 2013, A1. Location in patent: Paragraph 0094
[5] Angewandte Chemie - International Edition, 2017, vol. 56, # 42, p. 13011 - 13015
