65826-70-2

ANTI-DNASE1L3 (N-TERM) antibody produced in rabbit is suitable for western blot assay at a dilution of 1:250-1:500.

DNASE1L3 (Deoxyribonuclease I-like 3) is involved in residual nuclease activity of internucleosomal chromatin. In presence of Ca2+/Mg2+it produces 3μ-OH/5μ-P ends by cleaving both the DNA stranddouble-stranded and single-stranded DNA molecule. It has also been reported th at DNASE1L3 may cleave apoptotic DNA of thymocytesneuronal PC12 cellsC2C12 myoblasts and of cell lines expressing the recombinant nuclease. Mutation in DNASE1L3 causes a rare syndromehypocomplementemic urticarial vasculitis syndrome (HUVS).