6540-66-5

Name	2-Acetyl-3-methyl-5-methoxyphenol
CAS	6540-66-5
Molecular Formula	C10H12O3
Molecular Weight	180.2
MOL File	6540-66-5.mol

Synonyms

Acetoevernone 2-Acetyl-3-methyl-5-methoxyphenol 1-(2-Hydroxy-4-methoxy-6-methylphenyl)ethanone Ethanone, 1-(2-hydroxy-4-methoxy-6-methylphenyl)-

show less show more

Chemical Properties

Melting point	79 °C
Boiling point	321.8±37.0 °C(Predicted)
density	1.128±0.06 g/cm3(Predicted)
pka	9.90±0.15(Predicted)

Hazard Information

Uses

6’-Methyl paeonol is a paeonol derivative, which inihibits abnormal depolarizations and reduces the Amyloid β-induced ERK phosphorylation. 6’-Methyl paeonol exhibits alleviating activity against Alzheimer’s Disease[1].

Preparation

Preparation by partial methylation of 2,4-dihydroxy-6-methylacetophenone (orcacetophenone or b-orcacetophenone), with diazomethane (78%) or dimethyl sulfate.

in vivo

6’-Methyl paeonol (20 mg/kg, s.c.) ameliorates the impairment of memory and learning behavior in J20 mice^[1].

Animal Model:	APP transgenic C57BL/6 mice (J20 mice)^[1]
Dosage:	20 mg/kg
Administration:	subcutaneous injection
Result:	Reduced the time for mice reaching hidden platform.

References

[1] Chen PJ, et al., Derivative, 6'-Methyl Paeonol, Attenuates Aβ-Induced Pathophysiology in Cortical Neurons and in an Alzheimer's Disease Mice Model. ACS Chem Neurosci. 2024 Feb 21;15(4):724-734. DOI:10.1021/acschemneuro.3c00633

Supplier

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Zhuhai Aobokai Biomedical Technology Co., Ltd.

Telephone400-0628126

Websitehttp://www.aobchem.com.cn/

Related Products

54-47-7 166090-74-0

107761-42-2 15826-37-6

41372-20-7

PROMPT×

PROMPT
The What'sApp is temporarily not supported in mainland China

Cancel

Determine

Send Inquriy