Description
1,2-Dipalmitoyl-
13C-
sn-glycero-3-PC is intended for use as an internal standard for the quantification of 1,2-dipalmitoyl-
sn-glycero-3-PC by GC- or LC-MS. 1,2-Dipalmitoyl-
sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.
1,2,3,4 It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.
3 Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.
4
Uses
DPPC-13C2 is a deuterated labeled DPPC[1]. DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice[2][3][4][5][6].
References
1. Ege, C., and Lee, K.Y.C. Insertion of Alzheimer’s Aβ40 peptide into lipid monolayers Biophys. J. 87(3),1732-1740(2004).
2. Leekumjorn, S., and Sum, A.K. Molecular simulation study of structural and dynamic properties of mixed DPPC/DPPE bilayers Biophys. J. 90(11),3951-3965(2006).
3. Kalra, V.K., Sikka, S.C., and Sethi, G.S. Transport of amino acids in γ-glutamyl transpeptidase-implanted human erythrocytes J. Biol. Chem. 256(11),5567-5571(1981).
4. Uemura, A., Watarai, S., Iwasaki, T., et al. Induction of immune responses against glycosphingolipid antigens: Comparison of antibody responses in mice immunized with antigen associated with liposomes prepared from various phospholipids J. Vet. Med. Sci. 67(12),1197-1201(2005).
