64910-45-8

4-(Methylamino)-3-nitrobenzonitrile

A solution of 4-chloro-3-nitrobenzonitrile and methylamine was mixed and stirred in tetrahydrofuran, then concentrated and suspended in diethyl ether for filtration to obtain the crude product 4-methylamino-3-nitro-benzonitrile.

[1] Tran, G., Confair, D., Hesp, K. D., Mascitti, V., & Ellman*, J. A. (2017). C2-Selective Branched Alkylation of Benzimidazoles by Rhodium(I)-Catalyzed C–H Activation. Journal of Organic Chemistry, 82 17, 9243–9252. https://doi.org/10.1021/acs.joc.7b01723