64907-23-9

(3β)-3,25-Dihydroxycholest-5-en-7-one is a useful synthetic intermediate in the synthesis of 3β,7α,25-Trihydroxycholest-5-ene (T795075); a potent agonist of GPR183 that induces specific activation of the receptor.

ChEBI: 7-keto-25-hydroxycholesterol is an oxysterol, a 7-oxo steroid, a cholestanoid, a 3beta-sterol and a 3beta-hydroxy-Delta(5)-steroid.

7-keto-25-hydroxycholesterol (7k25OHC) might interact with the cysteine-rich domain (CRD) of the smoothened (Smo) in the hedgehog pathway. However7-keto-25-OHC is incapable of activating Smo.