64806-05-9

White Solid

A metabolite of Captopril. A new antihypertensive agent

ChEBI: An organic disulfide in which the disulfide bond links two units of captopril. It is a secondary metabolite of captopril.

Captopril disulfide is a metabolite and symmetrical disulfide form of the angiotensin converting enzyme (ACE) inhibitor captopril . Captopril disulfide is the main degradation product of captopril and is formed by oxidation. It is a potential impurity in commercial preparations of captopril. Captopril disulfide inhibits angiotensin I-induced increases in mean arterial pressure in anesthetized dogs (ID₅₀ = 0.231 mg/kg, i.v.).

50 g of free acid, 200 g of water and 66 g of ammonia were added to a 1000 ml three-necked flask. The reaction was held at a controlled temperature of 35°C for 2 hours. At the end of the reaction, control at this temperature dropwise addition of hydrochlo

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