ChemicalBook CAS DataBase List 64000-73-3

64000-73-3

Name	3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride
CAS	64000-73-3
Molecular Formula	C8H15N5O
MDL Number	MFCD00865910
Molecular Weight	197.24
MOL File	64000-73-3.mol

Hazard Information

Uses

Pildralazine (Propyldazine) is a hydralazinelike antihypertensive vasodilator containing a free hydrazine group. Pildralazine is orally active, has no significant carcinogenicity in mice model[1][2].

Definition

ChEBI: Pildralazine is a tertiary amino compound and a dialkylarylamine.

in vivo

Pildralazine (6-43 mg/kg; p.o.; once daily) shows no significant carcinogenicity in B6C3F1 and BALB/c mice under a long-term bioassay and a transplacental-infantile bioassay^[1].
Pildralazine and Hydralazine (HY-B0464A) act on a common receptor,sensitive to endogenous ATP and adenosine in the isolated tail artery from normotensive Wistar (NW) rats^[2].
Pildralazine (1 mg/kg; p.o.; ) significantly inhibits the onset of severe hypertension in spontaneously hypertensive rats (SHR) model^[3].

Animal Model:	Male and female B6C3F1 and to female BALB/c mice (8 weeks old)^[1]
Dosage:	100, 200, and 400 ppm dose: 8, 20, and 40 mg/kg/day in B6C3F1 males, 8, 22, and 43 mg/kg/day in B6C3F1 females, and 6, 15, and 34 mg/kg/day in BALB/c females, respectively
Administration:	Oral gavage; added in the drinking water; provided for 80 weeks, and observed for 130-133 weeks age
Result:	Resulted over 80% of mice alive beyond 78 weeks of age.

References

[1] Della Porta G, Dragani TA. Carcinogenicity study in mice on pildralazine, a hydralazinelike antihypertensive compound. J Cancer Res Clin Oncol. 1983;106(2):97-101. DOI:10.1007/BF00395386
[2] Chevillard C, et al. Interactions between hydralazine, propildazine and purines on arterial smooth muscle. Br J Pharmacol. 1981 Aug;73(4):811-7. DOI:10.1111/j.1476-5381.1981.tb08733.x
[3] Dorigotti L, et al. Effects of pildralazine alone and in combination on severe hypertension and cerebrovascular lesions in saline-drinking spontaneously hypertensive rats. Arzneimittelforschung. 1984;34(8):876-9. PMID:6541924

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