639858-32-5

BMS-605541 is a selective and orally active inhibitor of VEGFR-2 kinase with an IC50 value of 23 nM and Ki value of 49 nM. BMS-605541 inhibits the activity of Flk-1, VEGFR-1 and PDGFR-β with IC50 values of 40 nM, 400 nM and 200 nM, respectively. BMS-605541 can be used for cancer research[1].

VEGFR-2: 23 nM (IC₅₀); VEGFR-2: 49 nM (Ki); Flk-1: 40 nM (IC₅₀); VEGFR-1: 400 nM (IC₅₀); PDGFR-β: 200 nM (IC₅₀)

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[1] Borzilleri RM, et al. Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2. J Med Chem. 2006 Jun 29;49(13):3766-9. DOI:10.1021/jm060347y