638213-98-6

AGL-2263 is an insulin receptor and insulin-like growth factor (IGF) receptor inhibitor[1][2].

[1] Li Y, et al. GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5697-705. DOI:10.1073/pnas.1416675112
[2] Hua Zhang, et al. Somatic cells initiate primordial follicle activation and govern the development of dormant oocytes in mice. Curr Biol. 2014 Nov 3;24(21):2501-8. DOI:10.1016/j.cub.2014.09.023
[3] Ying Han, et al. Insulin mitigates apoptosis of porcine follicular granulosa cells by downregulating BimEL. Reprod Biol. 2019 Sep;19(3):293-298. DOI:10.1016/j.repbio.2019.08.003