637324-45-9

UCB-6876 is a novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control proteins.

UCB-6876 is a TNFα inhibitor and binds to asymmetrical crystal form of the TNF trimer (KD?=?22 μM)[1][2].

[1] Eguida M, et al. Unexpected similarity between HIV-1 reverse transcriptase and tumor necrosis factor binding sites revealed by computer vision. J Cheminform. 2021 Nov 23;13(1):90. DOI:10.1186/s13321-021-00567-3
[2] O'Connell J, et al. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun. 2019 Dec 19;10(1):5795. DOI:10.1038/s41467-019-13616-1