Uses
(+)-(s)-n-Methylsulfonylphenylalanyl chloride is used as a chiral reagent for the resolution of racemic alcohols via separation of the corresponding diastereomeric esters.
Preparation
(+)-(s)-n-Methylsulfonylphenylalanyl chloride is prepared from (S)-phenylalanine by reaction with Methanesulfonyl Chloride, followed by Phosphorus(V) Chloride.
storage
(+)-(s)-n-Methylsulfonylphenylalanyl chloride is best if prepared immediately prior to use. Can be stored at 0 °C under nitrogen for several days without appreciable decomposition.
Purification Methods
(+)-(s)-n-Methylsulfonylphenylalanyl chloride can be recrystallized from hexane/ether.
