62810-39-3

4’-Chloro-3-hydroxy-benzophenone is an impurity of Fenofibric acid (F248650), which is an active metabolite of Fenofibrate (F248640). 4’-Chloro-3-hydroxy-benzophenone can also be used to develop treatments for tuberculosis.

Preparation by diazotization of 3-amino-4?- chlorobenzo-phenone (SM), followed by hydrolysis of the diazonium salt obtained (81%), (84%). SM was obtained by Friedel–Crafts acylation of chlorobenzene with m-nitro-benzoyl chloride, followed by reduction of the resulting 4-chloro- 3?-nitrobenzophenone.