625403-59-0

Name	Benzamide, 3-methoxy-N-[4-(1-pyrrolidinyl)phenyl]-
CAS	625403-59-0
Molecular Formula	C18H20N2O2
Molecular Weight	296.36
MOL File	625403-59-0.mol

Synonyms

SBI-183 Benzamide, 3-methoxy-N-[4-(1-pyrrolidinyl)phenyl]-

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Chemical Properties

Boiling point	413.3±30.0 °C(Predicted)
density	1.200±0.06 g/cm3(Predicted)
form	Solid
pka	13.27±0.70(Predicted)
color	White to off-white

Hazard Information

Uses

SBI-183 is an orally active inhibitor of QSOX1 (Kd: 20 μM). SBI-183 suppresses the proliferative and invasive phenotype of renal cancer cell lines, including triple negative breast cancer cell line, lung adenocarcinoma cell line and pancreatic ductal adenocarcinoma. SBI-183 inhibits tumor growth in two human xenograft mouse models of renal cell carcinoma in vivo [1].

in vivo

SBI-183 (786-O: 400 μg/mouse/day, p.o., 35 days; RCJ-41T2: 100 mg/kg, p.o., 21 days) inhibits tumor growth in two independent human xenograft mouse models of renal cell carcinoma^[1].

Animal Model:	Human xenograft mouse models of renal cell carcinoma (786-O and RCJ-41T2)^[1]
Dosage:	400 μg/mouse/day (786-O); 100 mg/kg (RCJ-41T2)
Administration:	Oral gavage (p.o.)
Result:	Inhibited the growth of 786-O and RCJ-41T2 in vivo. Reduced laminin-α4 deposition in RCJ-41T2 mouse xenografts.

References

[1] Fifield, et al. Molecular Inhibitor of QSOX1 Suppresses Tumor Growth In Vivo. Molecular cancer therapeutics. 2020, 19(1), 112–122. DOI:10.1158/1535-7163.MCT-19-0233

Supplier

Shanghai EFE Biological Technology Co., Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Shaoguan Qicheng Biotechnology Co., Ltd

Telephone 18122215013

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1488808/0_EN.htm

TargetMol

Telephone400-821-0310 15002144251

Websitehttps://www.targetmol.cn/

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