ChemicalBook CAS DataBase List 62253-63-8

62253-63-8

Name	Epidermal Growth Factor
CAS	62253-63-8
EINECS(EC#)	263-468-7
Molecular Formula	NULL
MDL Number	MFCD00132565
Molecular Weight	6221.97
MOL File	62253-63-8.mol

Chemical Properties

storage temp.	2-8°C
form	powder
color	white
biological source	rabbit
Water Solubility	water: soluble, clear, colorless
InChIKey	GVUGOAYIVIDWIO-UFWWTJHBSA-N

Safety Data

WGK Germany	3
RTECS	KB4518000
F	10-21
HS Code	2937190000

Hazard Information

Chemical Properties

Endotoxin < 0.1 ng per μg (1EU/ug) of EGF

Description

An ophthalmic formulation of epidermal growth factor (urogastrone) has been launched for stimulation of healing of the corneal epithelium following various corneal diseases.

Originator

Inpharzam (Italy)

Uses

Epidermal Growth Factor, human, animal component free has been used:

as a supplement in in LHC-8 medium to culture liver cell lines
in the fetal bovine serum (FBS)-Dulbecco′s modified essential medium (DMEM) /F12 medium for primary culture of human glioma cells
as an additive in the conditional medium of normal fibroblasts (NFs) to study its effect on the migration and invasion of endometrial cancer (EC) cells
as a component in tumorsphere medium

Application

Epidermal Growth Factor (EGF) is a human protein that is involved in the regulation of cell growth, differentiation and survival. Recombinant EGF is an antigen binding molecule that can be used as a cancer treatment. Recombinant EGF has been shown to stimulate cellular transformation by binding to the epidermal growth factor receptor. It also has been shown to inhibit the growth of breast cancer cells with the HER2 gene mutation. The molecular weight of rec EGF is approximately 25 kDa and is composed of 165 amino acids. Recombinant EGF can be used in immunoassays, as a model system for studying biological properties, or as an antibody production tool.

Brand name

Gentel

General Description

Epidermal Growth Factor (EGF) is a small mitogenic polypeptide (～6 kDa), which is present in many mammalian species and is distributed throughout a wide number of tissues and body fluids.^? Human EGF is identical to β-urogastrone, a polypeptide which was recognized and isolated on the basis of its ability to inhibit gastric acid secretion.^? EGF is a member of a growth factor family, which is characterized by the presence of 6 conserved cysteine motifs that form three disulfide bonds. The location of 3 intrachain disulfide bonds in recombinant human EGF is identical to that of mouse EGF.^? EGF is homologous to a sequence contained in a 19 kDa protein of vaccinia virus,^? which appears to utilize the EGF receptor to gain entry into cell? EGF is mitogenic for a variety of epidermal and epithelial cells, including fibroblasts, glial cells, mammary epithelial cells, vascular and corneal endothelial cells, bovine granulosa, rabbit chondrocytes, HeLa cells, and SV40-3T3 cells.^?

Biochem/physiol Actions

Epidermal growth factor (EGF) helps to induce cell growth, proliferation and differentiation. It participates in the repairing of renal tissues in the kidney. It promotes the reabsorption of magnesium with the help of the transient receptor potential cation channel 6 (TRMP6). EGF is known to participate in the pathophysiology of drug-induced renal magnesium loss.

Supplier

Chengdu Youngshe Chemical Co., Ltd.

Telephone+86-17380623303 +86-17380623303

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Hangzhou Peptidego Biotech Co.,Ltd.

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Websitehttp://www.peptidego.com

Shanghai Aladdin Biochemical Technology Co.,Ltd.

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ACROBiosystems

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J & K SCIENTIFIC LTD.

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3B Pharmachem (Wuhan) International Co.,Ltd.

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Shijiazhuang Sdyano Fine Chemical Co., Ltd.

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Websitehttp://www.sdynchem.com

Nanjing Chemlin Chemical Co., Ltd

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Shanghai Hanhong Scientific Co.,Ltd.

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Chemsky (shanghai) International Co.,Ltd

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Wuhan Sunrise Technology Development Co., Ltd.

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Shenzhen Feiming Science and Technology Co.,Ltd.

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Dalian Meilun Biotech Co., Ltd.

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T&W GROUP

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Beijing HuaMeiHuLiBiological Chemical

Telephone010-56205725

Websitehttp://www.huabeibiochem.com/

Nanjing Sunlida Biological Technology Co., Ltd.

Telephone025-57798810

Websitehttp://www.sunlidabio.com

TargetMol Chemicals Inc.

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Websitehttps://www.targetmol.cn/

Shifang ShengYuan Technology Co., Ltd.

Telephone0838-6510595 13402890778 18881099744

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