62253-63-8
| Name | Epidermal Growth Factor |
| CAS | 62253-63-8 |
| EINECS(EC#) | 263-468-7 |
| Molecular Formula | NULL |
| MDL Number | MFCD00132565 |
| Molecular Weight | 6221.97 |
| MOL File | 62253-63-8.mol |
Synonyms
EGF
EGP
HEGF
NMEGF
RHEGF
HOMG4
LONG EGF
HUMAN URG
HUMAN EGF
MOUSE EGF
MURINE EGF
MURINE URG
EGF, HUMAN
EGF, MOUSE
NepiderMin
EGF, MURINE
MEGF (GRADE I)
REC EGF (HUMAN)
longtm egf human
HUMAN UROGASTRONE
MURINE UROGASTRONE
*recombinant expres
Human Oligopeptide-1
RECOMBINANT MOUSE EGF
RECOMBINANT HUMAN EGF
EPIDERMAL GROWTH FACTOR
Epithelial glycoprotein
REC EPIDERMAL GROWTH FACTOR
rhEGF, Human Oligopeptide-1
sH-Oligopeptide-1, Nepidermin
HUMAN EPIDERMAL GROWTH FACTOR
EPIDERMAL GROWTH FACTOR, HUMAN
EPIDERMAL GROWTH FACTOR, MOUSE
MURINE EPIDERMAL GROWTH FACTOR
EGF, MURINE SUBMAXILLARY GLAND
EPIDERMAL GROWTH FACTOR, MURINE
Epithelial cell surface antigen
Epidermal Growth Factor human,EGF
a-EpiderMal growth factor (huMan)
EGF-TM7-latrophilin-related protein
EPIDERMAL GROWTH FACTOR (EGF) HUMAN
REC EPIDERMAL GROWTH FACTOR (HUMAN)
RecoMbinantHuManEpiderMalGrowthFactor
Anti-TACD1 antibody produced in rabbit
EPIDERMAL GROWTH FACTOR, MOUSE (GRADE I)
HuMan RecoMbinant EpiderMal Growth Factor
EPIDERMAL GROWTH FACTOR, HUMAN, RECOMBINANT
Tumor-associated calcium signal transducer 1
Recombinant human epidermalgrowth factor (rhEGF)
sh-Oligopeptide-1/rh-Oligopeptide-1 (Human EGF)
EPIDERMAL GROWTH FACTOR, MURINE SUBMAXILLARY GLAND
EPIDERMAL GROWTH FACTOR, MURINE SUBMAXILLARY GLANDS
Epidermal Growth Factor, human, animal component free
Major gastrointestinal tumor-associated protein GA733-2
latrophilin and seven transmembrane domain-containing protein 1
EPIDERMAL GROWTH FACTOR HUMAN, RECOMBINA NT EXPRESSED IN E. COLI
Recombinant human epidermal growth factor (rhEGF) injectable grade
ASN-SER-ASP-SER-GLU-CYS-PRO-LEU-SER-HIS-ASP-GLY-TYR-CYS-LEU-HIS-ASP-GLY-VAL-CYS-MET-TYR-ILE-GLU-ALA-LEU-ASP-LYS-TYR-ALA-CYS-ASN-CYS-VAL-VAL-GLY-TYR-ILE-GLY-GLU-ARG-CYS-GLN-TYR-ARG-ASP-LEU-LYS-TRP-TRP-GLU-LEU-ARG
H-Asn-Ser-Asp-Ser-Glu-Cys-Pro-Leu-Ser-His-Asp-Gly-Tyr-Cys-Leu-His-Asp-Gly-Val-Cys-Met-Tyr-Ile-Glu-Ala-Leu-Asp-Lys-Tyr-Ala-Cys-Asn-Cys-Val-Val-Gly-Tyr-Ile-Gly-Glu-Arg-Cys-Gln-Tyr-Arg-Asp-Leu-Lys-Trp-Trp-Glu-Leu-Arg-OH
Hazard Information
Chemical Properties
Endotoxin < 0.1 ng per μg (1EU/ug) of EGF
Description
An ophthalmic formulation of epidermal growth factor (urogastrone) has been launched
for stimulation of healing of the corneal epithelium following various corneal diseases.
Originator
Inpharzam (Italy)
Uses
Epidermal Growth Factor, human, animal component free has been used:
- as a supplement in in LHC-8 medium to culture liver cell lines
- in the fetal bovine serum (FBS)-Dulbecco′s modified essential medium (DMEM) /F12 medium for primary culture of human glioma cells
- as an additive in the conditional medium of normal fibroblasts (NFs) to study its effect on the migration and invasion of endometrial cancer (EC) cells
- as a component in tumorsphere medium
Application
Epidermal Growth Factor (EGF) is a human protein that is involved in the regulation of cell growth, differentiation and survival. Recombinant EGF is an antigen binding molecule that can be used as a cancer treatment. Recombinant EGF has been shown to stimulate cellular transformation by binding to the epidermal growth factor receptor. It also has been shown to inhibit the growth of breast cancer cells with the HER2 gene mutation. The molecular weight of rec EGF is approximately 25 kDa and is composed of 165 amino acids. Recombinant EGF can be used in immunoassays, as a model system for studying biological properties, or as an antibody production tool.
Brand name
Gentel
General Description
Epidermal Growth Factor (EGF) is a small mitogenic polypeptide (～6 kDa), which is present in many mammalian species and is distributed throughout a wide number of tissues and body fluids.? Human EGF is identical to β-urogastrone, a polypeptide which was recognized and isolated on the basis of its ability to inhibit gastric acid secretion.? EGF is a member of a growth factor family, which is characterized by the presence of 6 conserved cysteine motifs that form three disulfide bonds. The location of 3 intrachain disulfide bonds in recombinant human EGF is identical to that of mouse EGF.? EGF is homologous to a sequence contained in a 19 kDa protein of vaccinia virus,? which appears to utilize the EGF receptor to gain entry into cell? EGF is mitogenic for a variety of epidermal and epithelial cells, including fibroblasts, glial cells, mammary epithelial cells, vascular and corneal endothelial cells, bovine granulosa, rabbit chondrocytes, HeLa cells, and SV40-3T3 cells.?
Biochem/physiol Actions
Epidermal growth factor (EGF) helps to induce cell growth, proliferation and differentiation. It participates in the repairing of renal tissues in the kidney. It promotes the reabsorption of magnesium with the help of the transient receptor potential cation channel 6 (TRMP6). EGF is known to participate in the pathophysiology of drug-induced renal magnesium loss.
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