Uses
2,5-Dichloro-2,5-dimethylhexane is a useful reagent for the preparation of substituted bis-2-indenyl metallocene compounds as catalysts for olefin polymerization.
Synthesis
2,5-Dimethyl-2,5-hexanediol was used as a raw material to synthesize 2,5-dichloro-2,5-dimethylhexane (Compound 2) by the method reported by Bruson H et al (J Am Chem Soc, 62:36, 1940). The procedure was as follows: 50 g of 2,5-dimethylhexane-2,5-diol (compound 1) was reacted with 1 L of concentrated hydrochloric acid. Upon completion of the reaction, the product was quantitatively measured to determine the yield. The physical and chemical properties of the resulting compound 2 were consistent with the data reported in the literature by Bruson et al.
References
[1] Patent: WO2007/5568, 2007, A1. Location in patent: Page/Page column 10
[2] Organometallics, 2012, vol. 31, # 21, p. 7579 - 7585
[3] Chinese Journal of Chemistry, 2010, vol. 28, # 10, p. 1951 - 1956
[4] Organic and Biomolecular Chemistry, 2018, vol. 16, # 35, p. 6586 - 6599
[5] Patent: EP1157047, 2003, B1
