A 23887
(5S,4'R)-3-Chloro-10,11-dihydro-N,N-dimethylspiro[5H-dibenzo[a,d]cycloheptene-5,1'-[2]cyclohexen]-4'-amine
[1S,4R]-3'-Chloro-10',11'-dihydro-N,N-dimethylspiro[2-cyclohexene-1,5'-[5H]dibenzo[a,d]cyclohepten]-4-amine
A23887 is a potentially neuroleptic tetracyclic spiro amine that has affinity for dopamine D-2 receptors. It is important for defining the pharmacophore for D-2 antagonist activity due to its limited conformational freedom.
Uses
A 23887 is a semirigid antipsychotic compound with considerable affinity for dopamine D2 receptor[1].
References
[1] Froimowitz M, et al. Conformational properties of semirigid antipsychotic drugs: the pharmacophore for dopamine D2 antagonist activity[J]. Journal of medicinal chemistry, 1991, 34(5): 1707-1714. DOI:10.1021/jm00109a026
