61638-08-2

ALEPH (hydrochloride) is the h5-HT2A and h5-HT2B partial agonist with the EC50 values of 10.3 nM and 19.2 nM, respectively. ALEPH (hydrochloride) causes head twitch response in mice (ED50: 0.80 mg/kg)[1].

Human 5-HT_2A Receptor; human 5-HT_2B Receptor

[1] Halberstadt AL, et al. Use of the head-twitch response to investigate the structure-activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines. Psychopharmacology (Berl). 2023 Jan;240(1):115-126. DOI:10.1007/s00213-022-06279-2