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Aspartylglutamate (Asp-Glu) is a dipeptide that exhibits excitatory activity, as it has been shown to depolarize CA1 pyramidal neurons and increase conductance in response to stimulation. Aspartylglutamate selectively binds to certain glutamate receptors and demonstrates potent effects in specific regions of the hippocampus, particularly in the stratum radiatum where it enhances excitatory neurotransmission.

ChEBI: A dipeptide formed from L-alpha-aspartyl and L-glutamic acid residues.

[1] Dipeptides of glutamate and aspartate may be endogenous neuroexcitants in the rat hippocampal slice DOI:10.1523/JNEUROSCI.05-06-01429.1985