ChemicalBook CAS DataBase List 615571-23-8

615571-23-8

Name	2-Chloro-3-(trifluoromethyl)-N-((S)-phenyl((S)-piperidin-2-yl)methyl)benzamide hydrochloride
CAS	615571-23-8
Molecular Formula	C20H20ClF3N2O.HCl
MDL Number	MFCD16628069
Molecular Weight	433
MOL File	615571-23-8.mol

Chemical Properties

storage temp.	4°C, away from moisture and light
form	Solid
color	White to off-white

Hazard Information

Uses

SSR504734 is an orally active, selective and reversible inhibitor of human, rat, and mouse GlyT1 (IC50=18, 15, and 38?nM, respectively). SSR504734 shows anti-schizophrenia, anti-anxiety and anti-depression activities[1].

in vivo

SSR504734 (i.p. and p.o.; 1-100 mg/kg; once) treatment shows good oral bioavailability^[1].
SSR504734 (i.p.; 30 mg/kg; once) induces a rapid and significant decrease of specific glycine uptake^[1].
SSR504734 (i.p.; 10 mg/kg; once) increases extracellular levels of Glycine in the prefrontal cortex (PFC) of freely moving rats^[1].

Animal Model:	Male Sprague-Dawley rats^[1]
Dosage:	1-100 mg/kg
Administration:	Intraperitoneal injection and oral gavage.; 1-100 mg/kg; once
Result:	Showed ID₅₀ values of 5.0 and 4.6?mg/kg for i.p. and p.o. treatments, respectively.

Animal Model:	Male Sprague-Dawley rats^[1]
Dosage:	30 mg/kg
Administration:	Intraperitoneal injection; 30 mg/kg; once
Result:	Maintained at about 80% inhibition from 1 to 7?h after administration.

Animal Model:	Male Sprague-Dawley rats^[1]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; 10 mg/kg; once
Result:	Produced a rapid and sustained increase in PFC extracellular levels of glycine.

IC 50

hGlyT1: 18 nM (IC₅₀); rGlyT1: 15 nM (IC₅₀)

storage

4°C, away from moisture and light

References

[1] Ronan Depoortère, et al. Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic. Neuropsychopharmacology. 2005 Nov;30(11):1963-85. DOI:10.1038/sj.npp.1300772

Spectrum Detail

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