61445-55-4

Yellow Oil

This N-nitrosamino acid has been isolated and identified in various types of tobacco, inlcluding snuff, chewing and pipe tobacco, cigars and cigarettes. The occurence of N-nitrosamino acids are highly correlated with levels of tobacco-specific N-nitrosamines which are known carcinogens in a wide range of animal species.

ChEBI: N-nitroso-N-methyl-4-aminobutyric acid is a nitrosamine that has methyl and 3-carboxypropyl substituents. It is a tobacco-derived nitrosamino acid that is a known animal and potential human carcinogen. It induces bladder transitional cell carcinomas in rats and has recently been identified as a contaminant in certain blood pressure medications. It has a role as a carcinogenic agent, a rat metabolite, a xenobiotic metabolite and a plant metabolite. It is a monocarboxylic acid and a nitrosamine.

Add 5.0 g (0.05 mol) of N-methylpyrrolidone to a 250 mL four-necked flask, add 50 g of toluene and stir to dissolve clear, . Add 0.5 g of tetrabutylammonium bromide, add aqueous sodium hydroxide solution (sodium hydroxide: 4 g (0.1 mol); water: 40 g), rai