613262-61-6

Name	6-(2-aMinophenoxy)benzo[d]isothiazol-3-aMine
CAS	613262-61-6
Molecular Formula	C13H11N3OS
MDL Number	MFCD21603930
Molecular Weight	257.311
MOL File	613262-61-6.mol

Synonyms

M62812 free base 6-(2-aMinophenoxy)benzo[d]isothiazol-3-aMine

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Hazard Information

Uses

M62812 (free base) is a toll-like receptor 4 (TLR4) signal transduction inhibitor. M62812 can suppress endothelial cell and leukocyte activation and prevents lethal septic shock in mice. M62812 can be used for the research of sepsis[1].

in vivo

M62812 (i.v.; 10-20 mg/kg; single) protects mice from lethality and reduced inflammatory and coagulatory parameters in a murine d-galactosamine-sensitized endotoxin shock model^[1].
M62812 (20 mg/kg/day) prevents mice from lethality in a murine cecal ligation and puncture model^[1].

Animal Model:	D-galactosamine-sensitized endotoxin shock mouse model^[1]
Dosage:	10-20 mg/kg
Administration:	Single intravenous administration
Result:	Suppressed LPS-induced leukocyte and endothelial cell activation in vivo. Prolonged survival in a d-galactosamine-sensitized endotoxin shock mouse model.

Animal Model:	A cecal ligation and puncture mouse model^[1]
Dosage:	20 mg/kg
Administration:	Intravenous administration; Everyday
Result:	Reduced mortality in a murine cecal ligation and puncture model.

References

[1] Nakamura M, et al. Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur J Pharmacol. 2007;569(3):237-243. DOI:10.1016/j.ejphar.2007.05.013

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TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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