612527-56-7

Name	HZ166 thyl 8-ethynyl-6-(2-pyridyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
CAS	612527-56-7
Molecular Formula	C21H16N4O2
MDL Number	MFCD32670717
Molecular Weight	356.38
MOL File	612527-56-7.mol

Synonyms

HZ166 thyl 8-ethynyl-6-(2-pyridyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-ethynyl-6-(2-pyridinyl)-, ethyl ester

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Chemical Properties

storage temp.	2-8°C
solubility	DMSO: 2mg/mL, clear
form	powder
color	white to beige

Hazard Information

Uses

HZ166 is a GABAA receptor subtype-selective benzodiazepine site agonist with preferential activity at α2- and α3-GABAA receptors. HZ166 shows anti-hyperalgesic effects[1]. HZ166 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Biological Activity

HZ-166 is a potentnon-sedative GABAA receptor subtype-selective benzodiazepine site agonist exhibits preference toward α2- and α3-GABAARs. HZ-166 exhibits antihyperalgesic properties in mice models of neuropathic and inflammatory painwithout sedation and motor impairment.

References

[1] Alessandra Di Lio, et al. HZ166, a novel GABAA receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic pain. Neuropharmacology. 2011 Mar;60(4):626-32. DOI:10.1016/j.neuropharm.2010.11.026

Supplier

Nanjing Shizhou Biology Technology Co.,Ltd

Telephone025-85560043 15850508050

Websitehttp://www.synzest.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Merck KGaA

Telephone21-20338288

Websitehttp://www.sigmaaldrich.cn

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