Chemical Properties
Tan Solid
Uses
A labelled endogenous Sigma-1 receptor regulator.
Uses
It is an endogenous Sigma-1 receptor regulator.
Definition
ChEBI: A tryptamine derivative having two N-methyl substituents on the side-chain.
General Description
Dimethyltryptamine is a very weak hallucinogen, activeonly by inhalation or injection, with a short duration of action.It possesses pronounced sympathomimetic (NE) sideeffects.
Biological Activity
Endogenous σ 1 receptor ligand and psychoactive plant compound (K i = 14.8 μ M). Binding to σ 1 inhibits voltage-gated Na + channels and is responsible for the behavioral effects of DMT. Also a 5-HT 2A receptor agonist and inhibitor of 5-HT uptake at plasma membrane serotonin transporters (SERT) (K i = 4.0 μ M).