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4''-O-methyl Quercetin is a flavonoid isolated from C. ordata with anticancer and antiplasmodial activity. 4''-O-methyl Quercetin is a major metabolite of quercetin (Item No. 10005169) that inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC₅₀ values ranging from 5.5-24.1 μM. It induces G₂-M arrest and inhibits tubulin polymerization in vitro in a dose-dependent manner. 4''-O-methyl Quercetin inhibits breast cancer resistance protein (BCRP/ABCG2; IC₅₀ = 40 nM in a vesicular transport assay) with no cellular toxicity indicating potential for use in overcoming multidrug resistance in chemotherapy. 4''-O-methyl Quercetin also reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC₅₀ = 4.8 μM) and suppresses infection in mice (65-81% suppression at 2.5-5 mg/kg dose).

A major metabolite of the flavanoid Quercetin (Q509500) with antioxidant properties. It helps to protect H9c2 cardiomyoblasts against H2O2-induced oxidative stress via the modulation of PI3K/Akt and ERK1/2 signaling pathways.

ChEBI: A monomethoxyflavone that is quercetin methylated at position O-4'. Isolated from Cyperus teneriffae.

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[1] FABIO NICOLINI. Induction of G2/M phase arrest and apoptosis by the flavonoid tamarixetin on human leukemia cells.[J]. Molecular Carcinogenesis, 2014, 53 12: 939-950. DOI: 10.1002/mc.22055
[2] KEE W. TAN . Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2)[J]. Food Chemistry, 2013, 138 4: Pages 2267-2274. DOI: 10.1016/j.foodchem.2012.12.021
[3] I C EZENYI. Antiplasmodial activity-aided isolation and identification of quercetin-4’-methyl ether in Chromolaena odorata leaf fraction with high activity against chloroquine-resistant Plasmodium falciparum.[J]. Parasitology Research, 2014, 113 12: 4415-4422. DOI: 10.1007/s00436-014-4119-y