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A pyrrolizidine alkaloid, petasitenine occurs, together with neopetasitenine (q.v.) in Petasites japonicus Maxim. Like the accompanying base, it possesses strong hepatotoxic properties.

Petasitenine (Fukinotoxin) is a pyrrolizidine alkaloid that can be found in the plant Petasites japonicus, which is a carcinogenic metabolite of neopetasitenine. Petasitenine causes lactate dehydrogenase leakage, and exhibits hepatotoxicity[1].

ChEBI: Petasitenine is a spiro-epoxide.

Questionable carcinogen with experimental carcinogenic data.Mutation data reported. Used as a food and herbal remedy. When heated to decomposition it emits toxic fumes of NOx.

Yamada etal., Chem.Lett.,461 (1976)