5980-33-6

4-Methylumbelliferone Sodium Salt forms a complex with metals such as copper (II), zinc (II), nickel (II), cobalt (II) and iron (III) which displays spasmolytic activity. Also, it inhibits the hyaluronan acid in cultured human skin fibroblasts.

4-methylumbelliferone (4-MU) serves as a hyaluronan (HA) synthesis blocker. It exhibits anti-inflammatoryanti-fibrogenicand antitumor properties. 4-MU is used to tre at biliary spasms and might also be beneficial in nonalcoholic steatohepatitis (NASH)inflammationhepatocyte injuryand fibrotic response. 4-MU is known to be glucuronidated by most of the uridine 5ฺ-diphospho-glucuronosyltransferase (UGT) isoforms of the human liver. This makes it a potent probe substrate to examine the overall hepatic UGTs activity.