59695-59-9

Name	Cephalexin (hydrochloride)
CAS	59695-59-9
Molecular Formula	C16H18ClN3O4S
MDL Number	MFCD08141797
Molecular Weight	383.85
MOL File	59695-59-9.mol

Synonyms

Cephalexin (hydrochloride) (6R,7R)-7-[[(2R)-Aminophenylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrochloride (1:1)

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Chemical Properties

storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Powder
color	Light yellow to yellow

Hazard Information

Uses

Cephalexin (Cefalexin) hydrochloride is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) hydrochloride has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) hydrochloride targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) hydrochloride is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al[1][2].

in vivo

Cephalexin (Cefalexin) hydrochloride (0-50 mg/kg; p.o.; for 3.5 hours) has antibacterial activity in male Swiss-Webster mice with infected bacterial^[2].

Animal Model:	Male Swiss-Webster mice with infected bacterial^[2]
Dosage:	0-50 mg/kg
Administration:	Oral administration; for 3.5 hours
Result:	Had antibacterial activity against Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus and several gram-negative species mice.

IC 50

β-lactam

storage

Store at -20°C

References

[1] Cho H, et, al. Beta-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery. Cell. 2014 Dec 4;159(6):1300-11. DOI:10.1016/j.cell.2014.11.017
[2] Buck RE, et, al. Cefadroxil, a new broad-spectrum cephalosporin. Antimicrob Agents Chemother. 1977 Feb;11(2):324-30. DOI:10.1128/AAC.11.2.324

Supplier

MedBioPharmaceutical Technology Inc

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