586976-24-1

CTPB (586976-24-1) is a selective activator of p300 HAT (histone acetyltransferase) selective over PCAF (p300 CPB-associated factor).1,2

CTPB is an amide derivative that selectively activates the histone acetyltransferase (HAT) p300, with maximal activation at 275 μM. It directly binds p300. CTPB does not alter PCAF HAT or histone deacetylase activity. It dose-dependently increases the acetylation of histones H3 and H4, with maximal effect at 200 μM.

ChEBI: CTPB is a benzamide obtained by formal condensation of the carboxy group of 2-ethoxy-6-pentadecylbenzoic acid with one of the amino groups of 4-chloro-3-(trifluoromethyl)aniline. It has a role as a histone acetyltransferase activator. It is a member of benzamides, an aromatic ether, a member of monochlorobenzenes and an organofluorine compound.

CBP/p300

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1) Balasubramanyam?et al.?(2003),?Small molecule modulators of histone acetyltransferase p300; J. Biol. Chem.,?278?19134 2) Mantelingu?et al.?(2007),?Activation of p300 histone acetyltransferase by small molecules altering enzyme structure: probed by surface-enhanced Raman spectroscopy; J. Phys. Chem. B.,?111?4527