Aspidin BB is a phloroglucinol derivative, which can be isolated from the aerial part of Dryopteris championii. Aspidin BB has anticancer activity. Aspidin BB induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells[1][2].
Definition
ChEBI: Aspidin is a carboxylic ester. It is functionally related to a phloroglucinol.
IC 50
Bcl-2; Bax; Caspase-3
References
[1] Sun Y, et al. Aspidin BB, a phloroglucinol derivative, induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells. Chem Biol Interact. 2013 Jul 5;204(2):88-97. DOI:10.1016/j.cbi.2013.04.008 [2] Chen NH, et al. Drychampones A-C: Three Meroterpenoids from Dryopteris championii. J Org Chem. 2016 Oct 7;81(19):9443-9448. DOI:10.1021/acs.joc.6b01720
