58337-35-2

Name	elliptinium acetate
CAS	58337-35-2
EINECS(EC#)	261-216-0
Molecular Formula	C20H20N2O3
MDL Number	MFCD00866541
Molecular Weight	336.384
MOL File	58337-35-2.mol

Synonyms

H9m2E Elliptinium Ellipticine analog elliptinium acetate Ellipticine acetomethylate NSC 264137|||Celiptium|||NSC 264137 2-Methyl-9-hydroxyellipticinium acetate 9-Hydroxy-2-methylellipticinium acetate N2-Methyl-9-hydroxyellipticinium acetate 2,5,11-trimethyl-6H-pyrido[4,3-b]carbazol-2-ium-9-ol:acetate 6H-Pyrido[4,3-B]carbazolium, 9-hydroxy-2,5,11-trimethyl-acetate (salt)

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Hazard Information

Uses

Elliptinium acetate (NSC 264137) is a DNA intercalating agent that is highly cytotoxic to L1 210 cells and covalently binds to nucleic acids from L1210 cells. Elliptinium acetate can be used in cancer research, particularly in metastatic breast cancer[1][2].

Anticancer Research

It is an ellipticine derivative and is obtained from Bleekeria vitensis, a Fijian medicinalplant. It is used to treat breast cancer (Shoeb 2006).

References

[1] Dugue B, et al. Covalent binding of elliptinium acetate (NSC 264137) to nucleic acids of L1210 cells in culture. Cancer Res. 1986 Aug;46(8):3828-33. PMID:2425935
[2] Arteaga CL, et al. Elliptinium, a DNA intercalating agent with broad antitumor activity in a human tumor cloning system. Eur J Cancer Clin Oncol. 1987 Nov;23(11):1621-6. DOI:10.1016/0277-5379(87)90440-8

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TargetMol Chemicals Inc.

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Websitehttps://www.targetmol.cn/

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