5799-75-7

General method: Potassium carbonate (25.41 mmol) was added to an N,N-dimethylformamide (DMF) mixture of 3-bromopropargyl (8.47 mmol) and hexahydropyridine (16.94 mmol), and the reaction mixture was stirred at room temperature for 10-12 hours. After completion of the reaction, the reaction mixture was quenched with ice water and extracted with ethyl acetate. The organic layers were combined and dried over anhydrous sodium sulfate, followed by evaporation of the solvent under reduced pressure to give 1-alkynylpiperidine.

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