5778-80-3

7-Methoxytacrine (7-MEOTA) is an inhibitor of human acetylcholinesterase (hAChE) with an IC50 value of 10 μM, and can be used for the research of Alzheimer's disease (AD)[1].

hAChE: 10.5 μM (IC₅₀); hBCHE: 21 μM (IC₅₀)

[1] Spilovska K, et al. 7-Methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in Alzheimer's disease treatment--synthesis, biological evaluation and molecular modeling studies. Molecules. 2013;18(2):2397-2418. Published 2013 Feb 20. DOI:10.3390/molecules18022397