57-30-7

Name	Phenobarbital sodium
CAS	57-30-7
EINECS(EC#)	200-322-3
Molecular Formula	C12H10N2Na2O3
MDL Number	MFCD00036211
Molecular Weight	276.2
MOL File	57-30-7.mol

Chemical Properties

Appearance	Solution S is clear (2.2.1) and not more intensely coloured than reference solution Y7 (2.2.2, Method II).
Melting point	175°C
solubility	H₂O: 1 g/mL
PH	pH (100g/l, 25℃) : 9.0～11.0
Water Solubility	>=10 g/100 mL at 20 ºC
Merck	13,7319
BRN	3802044
CAS DataBase Reference	57-30-7(CAS DataBase Reference)
EPA Substance Registry System	57-30-7(EPA Substance)

Safety Data

Hazard Codes	T
Risk Statements	R25:Toxic if swallowed. R40:Limited evidence of a carcinogenic effect. R43:May cause sensitization by skin contact. less more
Safety Statements	S22:Do not breathe dust . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . less more
RIDADR	UN 2811 6.1/PG 3
WGK Germany	-
RTECS	CQ7000000
HazardClass	6.1(b)
PackingGroup	III
Safety Profile	Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion, intravenous, intraperitoneal, intraduodenal, and subcutaneous routes. Human systemic effects by ingestion: nausea or vomiting and coma. Experimental reproductive effects. Mutation data reported. Used to treat epilepsy, as a hypnotic and sedative. When heated to decomposition it emits toxic fumes of NOx and NazO. See also BARBITURATES less more
Toxicity	LD50 orally in rats: 660 mg/kg (Schaffarzick, Brown) less more

Hazard Information

General Description

Odorless white crystalline powder. Aqueous solutions are alkaline to litmus and phenolphthalein (pH approximately 9.3). Bitter taste. A narcotic.

Reactivity Profile

SODIUM PHENOBARBITAL(57-30-7) can react with strong oxidizing agents. Incompatible with ammonium salts and chloral hydrate. Also incompatible with acids and acidic substances .

Air & Water Reactions

Hygroscopic. May be sensitive to prolonged exposure to air. Water soluble. Aqueous solutions are unstable, but may be kept at or below 50°F for a few days.

Fire Hazard

Flash point data for this chemical are not available; however, SODIUM PHENOBARBITAL is probably combustible.

Chemical Properties

Solution S is clear (2.2.1) and not more intensely coloured than reference solution Y7 (2.2.2, Method II).

Uses

Anticonvulsant; sedative-hypnotic.

Definition

ChEBI: A barbiturate that is the sodium salt of phenobarbital (barbituric acid substituted at C-5 by ethyl and phenyl groups).

Brand name

Luminal Sodium (Sterling Winthrop).

Biochem/physiol Actions

Phenobarbital, a substituted barbituric acid is an antileptic drug and is not easily eliminated from circulation. It hyperpolarizes the synaptic neuronal membranes by favoring the activation of neuronal postsynaptic GABAA?receptors by γ aminobutyric acid (GABA). Phenobarbital is also effective in treating neonatal seizures and status epilepticus.

Material Safety Data Sheet(MSDS)

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