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Prostaglandin F synthase (PGF synthase) is a member of the aldo-keto reductase superfamily of proteins which catalyze the conversion of aldehydes and ketones to thier corresponding alcohols. Prostaglandin F synthase is used in cancer research since it is upregulated in many cancers such as breast and prostate cancer. PGF synthase is also used to study kidney and renal cell carcinoma .

PGF synthase catalyzes the conversions of 4-androstene-3,17-dione to testosteroneestrone to 17β-estradiolprostaglandin H2 to PGF2α and PGD2 to 9α,11β-PGF2. Prostaglandin (PG) F2 is synthesized via three pathways .