Chemical Properties
White prismatic crystals or powder cannot coexist with strong oxidizing agents, aluminum, copper, copper alloy, and nickel. Glycyl-glycyl-glycine has a strong complexing ability and can form stable chelates with different metal ions due to its small molecule size and ability to provide four coordination bonds for metal ions.
Uses
Glycyl-glycyl-glycine is used as a model peptide for studies of physicochemical parameters and molecular associations of small peptides. It is also used as a copper chelator.
Uses
Substrate for tripeptide aminopeptidase.
Application
Glycyl-glycyl-glycine is commonly used in the food, pharmaceutical, and cosmetic industries as an ingredient in skin and hair care products. It is also used as a dietary supplement due to its ability to improve digestion and promote the growth of healthy gut bacteria.
Definition
ChEBI: Glycyl-glycyl-glycine is a tripeptide in which three glycine units are linked via peptide bonds in a linear sequence. It is a tautomer of a Gly-Gly-Gly zwitterion.
General Description
Gly-Gly-Gly or triglycine is a flexible peptide linker with three glycine residues linked by peptide bonds in a linear sequence. Gly-linkers link multiple domains in a single protein without affecting the function of each domain.
Biochem/physiol Actions
Substrate for reproducible serum protein measurements by the biuret reaction and for the assay of aminotripeptidases.
Purification Methods
Crystallise triglycine from H2O or H2O/EtOH and dry it at 110o. [Yakel & Hughes Acta Cryst 5 847 1952, Lenel et al. Acta Cryst 3 313 1952, Holley & Holley J Am Chem Soc 74 3072 1952, Beilstein 4 III 1198, 4 IV 2469.]
