Description
A Senecio alkaloid also present in S. Jacobea, this base has [α] D - 140° (CHC13)
and is hydrolyzed to retronecine and jacozinecic acid. The base contains a
methylene group and the ultraviolet spectrum has a single absorption maximum
at 233 mμ.
Definition
ChEBI: Jacozine is a pyrrolizine alkaloid that is seneciphylline in which the exocyclic double bond has been converted to the corresponding epoxide. It has a role as a Jacobaea metabolite. It is a macrocyclic lactone, an organic heterotricyclic compound, a pyrrolizine alkaloid, a spiro-epoxide, a tertiary alcohol and a tertiary amino compound. It is functionally related to a seneciphylline.
References
Bradbury, Culvenor., Chern. & Ind., 1021 (1954)
Bradbury, Culvenor.,Austrai. J. Chern., 7,378 (1954)
Bradbury, Willis., ibid, 9,258 (1956)
Culvenor., ibid, 17,233 (1964)
