Uses
Wybutosine or yW, is a nucleoside modification seen in archaeal and eukaryal tRNAPhe at position 37 and it is belongs in the wyeosine family of tricyclic ribonucleosides. Wyosine derivatives are vastly diverse in Archaea and the study of isowyosine is of interest in the proposition of a shared ancestor with a common biosynthetic pathway shared between Archaea and Eukaryotes. Wybutosine has been studied in relation to S-adenosylmethionine (SAM) enzymes, which can cause an array of human diseases due to aberrations in gene encoding and ribonucleosiide modifications.
Definition
ChEBI: Wybutosine is a nucleoside analogue having methyl (2S)-4-(4,6-dimethyl-9-oxo-4,9-dihydro-3H-imidazo[1,2-a]purin-7-yl)-2-[(methoxycarbonyl)amino]butanoate as the modified nucleobase. It is a nucleoside analogue, a methyl ester and a carbamate ester. It is functionally related to a guanosine.
