54642-23-8

JNK inhibitor II, negative control is the methylated analog of JNK inhibitor II and exhibits a lower affinity for JNK2 and JNK3. This compound is suitable to be used as a negative control in various kinase assays.

A useful negative control for JNK Inhibitor II (SP600125, Cat. No. 420119). Inhibits JNK2 and JNK3 only at much higher concentrations (IC₅₀ = 18 μM and 24 μM, respectively) compared to SP600125 (IC₅₀ = 40 nM and 90 nM, respectively).

Target IC50: 18 μM and 24 μM against JNK2 and JNK3, respectively