5440-00-6

Pale Brown Solid

Reactant involved in the synthesis of biologically active molecules including:• ;1H-Imidazol-1-yl substituted 8-phenylxanthines for use as adenosine receptor ligands1• ;Pyrimidinyl purinediones via cyclocondensation2• ;Theophylline derivatives as adenosine receptor antagonists3• ;Pteridine analogs for use as monoamine oxidase B and nitric oxide synthase inhibitors4• ;Fused tricyclic xanthines5• ;Cadmium uraciliminoethylpyridine complexes for use as antiproliferatives against C6 glioma cells6

It recrystallises from EtOH. The hydrochloride has m 310o (from MeOH), and the perchlorate has m 246-248o. [UV: Bredereck et al. Chem Ber 92 583 1959, Taylor et al. J Am Chem Soc 77 2243 1955, Beilstein 25 III/IV 4133.]