Mitogen-activated protein kinase kinase kinase kinase 6
Chemical Properties
form
buffered aqueous solution
biological source
rabbit
Specific Activity
16-22nmol/min·mg
Safety Data
WGK Germany
nwg
Storage Class
10 - Combustible liquids
Hazard Information
Uses
Anti-MAP4K6 Antibody detects endogenous levels of total MAP4K6 protein.
Biological Activity
Misshapen/NIKs-related kinase 1 (MINK1) plays a vital role in modulating various cellular process such as actin cytoskeleton rearrangementcell matrix adhesioncell-cell adhesioncell morphologyand survival. It is also implicated in the cell motility and cell invasion. Kinase inactive mutant of MINK1 increased cell spreadingactin stress fiber formationadhesion to extracellular matrix and inhibited cell motility and invasion. Thusalteration in the MINK1 activity inhibits tumor development. MINK is activated after Ras induction via a method involving reactive oxygen species (ROS). This activated MINK triggers the activity of p38 stress-activated kinase via MAP3K (Mitogen-Activated Protein Kinase Kinase Kinase) 5/8 and MKK (mitogen-activated protein kinase kinase) 3/6which leads to p53-independent induction of cyclin-dependent kinase inhibitorp21WAF1/CIP1 and permanent cell cycle arrest. MINK1 has an essential role in abscissionwhich is a final stage of cytokin
