543700-68-1

Name	1-cyclopropyl-3-((1-(4-hydroxybutyl)-1H-benzo[d]imidazol-2-yl)methyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one
CAS	543700-68-1
Molecular Formula	C21H23N5O2
Molecular Weight	377.44
MOL File	543700-68-1.mol

Synonyms

BMS-433771 free base BMS433771 (BMS-433771) BMS 433771 free base,BMS433771 free base 2H-Imidazo[4,5-c]pyridin-2-one, 1-cyclopropyl-1,3-dihydro-3-[[1-(4-hydroxybutyl)-1H-benzimidazol-2-yl]methyl]-

show less show more

Chemical Properties

Boiling point	611.8±45.0 °C(Predicted)
density	1.42±0.1 g/cm3(Predicted)
form	Solid
pka	15.11±0.10(Predicted)
color	White to off-white

Hazard Information

Uses

BMS-433771 is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 can be used for the research of respiratory tract disease[1][2].

in vivo

BMS-433771 (p.o.; 1-200 mg/kg; single or bid 4 days) shows prophylactic efficacy via oral dosing, but has considerable pharmacodynamic differences between the two rodent models^[2]
.

Animal Model:	rodent models of RSV infection^[2] (cotton rat and mice)
Dosage:	1, 10, and 50 mg/kg (mice); 25, 50, 100, and 200 mg/kg (rat)
Administration:	oral, single or bid 4 days
Result:	Had prophylactic efficacy via oral dosing in both animal models. Showed RSV infection more sensitive to inhibition in the BALB/c mouse host than in the cotton rat.

References

[1] Christopher Cianci, et al. Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor. J Antimicrob Chemother DOI:10.1093/jac/dkh558
[2] Christopher Cianci, et al. Oral efficacy of a respiratory syncytial virus inhibitor in rodent models of infection. Antimicrob Agents Chemother. 2004 Jul;48(7):2448-54. DOI:10.1128/AAC.48.7.2448-2454.2004

Supplier

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Zhejiang Huida Biotech Co., Ltd.

Telephone0571-89903022 18679456698

Websitehttps://www.huidacollection.cn

Hangzhou MolCore BioPharmatech Co.,Ltd.

Telephone+86-057181025280; +8617767106207

Websitehttps://www.molcore.com/

PROMPT×

PROMPT
The What'sApp is temporarily not supported in mainland China

Cancel

Determine

Send Inquriy