539857-64-2

Name	Benzamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, hydrochloride (1:1)
CAS	539857-64-2
Molecular Formula	C14H16ClN3O
MDL Number	MFCD06407678
Molecular Weight	277.75
MOL File	539857-64-2.mol

Synonyms

WF-536 Hydrochloride Benzamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, hydrochloride (1:1)

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Hazard Information

Description

WF-536 Hydrochloride is a novel inhibitor of ROCK, inhibiting tumour metastasis in some animal models.

Uses

WF-536 is an orally active inhibitor of Rho-associated coiled-coil-containing protein kinase (ROCK). WF-536 has tumor anti-metastatic activity. WF-536 can be used for the research of cancer[1].

in vivo

WF-536 (oral; 0.3-3 mg/kg/day; for 28 days) inhibits Lewis lung carcinoma (LLC) metastasis and LLC-induced angiogenesis in mice^[1].

Animal Model:	C57BL/6 mice (male, 6-week old)^[1]
Dosage:	0.3, 1, 3 mg/kg
Administration:	Oral; daily; for 28 days
Result:	Significantly reduced the number of pulmonary metastatic colonies of LLC in a dose-dependent manner (0.3- 3 mg/kg).

References

[1] Nakajima, Masahide et al. Wf-536 prevents tumor metastasis by inhibiting both tumor motility and angiogenic actions. European journal of pharmacology vol. 459,2-3 (2003): 113-20. DOI:10.1016/s0014-2999(02)02869-8

Supplier

Jinan Jiuli Biotechnology Co. , Ltd.

Telephone 15865264761

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList89365/0_EN.htm

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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