53595-18-9

ADPRP is an intranuclear enzyme whose main activity is to use NAD+ (nicotinamide adenine dinucleotide) as a substrate to add ADP-ribose units to chromatin-bound proteins, including the ADPRP enzyme itself. This process, called poly(ADP-ribosylation), is a post-translational modification that regulates the interaction between DNA and nuclear proteins[1].

[1] Yamanaka H, et al. Human autoantibodies to poly (adenosine diphosphate-ribose) polymerase[J]. The Journal of clinical investigation, 1987, 80(3): 900-904. DOI:10.1172/JCI113150