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TP3011 is an active metabolite of CH-0793076 and is a potent topoisomerase I inhibitor equipotent as SN38. TP3011 is against cancer cell lines growth with IC50s at the range sub-nanomolar in vitro.

TP3011 (CH0793011) is an active metabolite of CH-0793076 and is a potent?topoisomerase I?inhibitor equipotent as SN38[1]. TP3011 is against cancer cell lines growth with IC50s at the range sub-nanomolar in vitro[2].

Topoisomerase I

[1] Anthoney DA, et al. Phase I study of TP300 in patients with advanced solid tumors with pharmacokinetic, pharmacogenetic and pharmacodynamic analyses.BMC Cancer. 2012 Nov 21;12:536. DOI:10.1186/1471-2407-12-536
[2] Niizuma S, et al. Synthesis of new camptothecin analogs with improved antitumor activities.Bioorg Med Chem Lett. 2009 Apr 1;19(7):2018-21. DOI:10.1016/j.bmcl.2009.02.031